Developing electrically active materials to repair damaged hearts

When a heart attack occurs, muscle in the heart tissue can be scarred, interfering with electrical activity necessary for healthy heart function. Drug treatments are available that alleviate further damage, but these don’t lead to tissue regeneration. Using artificial materials to patch or rebuild damaged parts has been tried but only recently has work focused … Read more

Controlling our internal world

Olympic skaters can launch, perform multiple aerial turns, and land gracefully, anticipating imperfections and reacting quickly to correct course. To make such elegant movements, the brain must have an internal model of the body to control, predict, and make almost instantaneous adjustments to motor commands. So-called “internal models” are a fundamental concept in engineering and … Read more

Yale researchers develop way to help brain organoids thrive

Brain organoids created from human embryonic stem cells offer scientists a powerful way to study the developing brain in three dimensions. However, organoids need nutrients and oxygen carried in blood to thrive, just as a developing fetal brain does. Now Yale researchers have developed a method to induce growth of blood vessels in organoids and … Read more

Tufts’ scientists create brain-mimicking environment to grow 3D tissue models of brain tumors

A team of Tufts University-led researchers has developed three-dimensional (3D) human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, a significant advancement for the study of brain tumor biology and pharmacological response. The study was published today in Nature Communications. The researchers created models that include brain-derived extracellular matrix (ECM) – … Read more

Implanted memories teach birds a song

A father holds up his newborn, their faces only inches apart, and slowly repeats the syllables “da” and “dee.” After months of hearing these sounds, the baby begins to babble and gradually “da da da” is refined to the word “Daddy.” Speech is learned. These are critical steps in our intellectual development, yet many of … Read more

Breakthrough in sex-chromosome regulation

Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine. The study is published in Nature Structural and Molecular Biology. The … Read more

Sentinels in the mouth

Newly discovered chemical-sensing cells in the gums protect the mouth by standing guard against infections that damage soft tissue and destroy the bone that supports the teeth, report researchers from the Monell Chemical Senses Center in an animal study published this week in Nature Communications. With the help of bitter taste receptors that also detect byproducts … Read more

New research finds coastal living linked with better mental health

Living close to the sea could support better mental health in England’s poorest urban communities, finds a new study published today in the journal Health and Place. Researchers from the University of Exeter used survey data from nearly 26,000 respondents in their analysis, which marks one of the most detailed investigations ever into the wellbeing effects … Read more

Keep organs cool for transplantation

Rapid cooling of animal and human donor hearts may decrease accumulation of a chemical that damages the tissue after transplantation, according to a new study in Nature Metabolism. These findings explain why cold organ storage is beneficial for organ preservation, and they may also lead to improved solutions for more efficient use of the limited pool … Read more