Comparative genetic architectures of schizophrenia in East Asian and European populations

As we all know, schizophrenia is a debilitating psychiatric disorder with prevalence of about ~1% lifetime risk across different populations. However, previously literatures mainly reported in European populations and the results remained ungeneralizable. The present study has explored the biological insights of schizophrenia in the largest sample size of East Asian populations up to now. … Read more

Evidence that tobacco smoking increases risk of depression and schizophrenia

A new study published today [6 Nov] in Psychological Medicine and led by University of Bristol researchers has found that tobacco smoking may increase your risk of developing depression and schizophrenia. It is well known that smoking is much more common amongst people with mental illness – especially depression and schizophrenia. However, most studies that have looked … Read more

Biomarker for schizophrenia can be detected in human hair

Working with model mice, post-mortem human brains, and people with schizophrenia, researchers at the RIKEN Center for Brain Science in Japan have discovered that a subtype of schizophrenia is related to abnormally high levels hydrogen sulfide in the brain. Experiments showed that this abnormality likely results from a DNA-modifying reaction during development that lasts throughout … Read more

Yale researchers develop way to help brain organoids thrive

Brain organoids created from human embryonic stem cells offer scientists a powerful way to study the developing brain in three dimensions. However, organoids need nutrients and oxygen carried in blood to thrive, just as a developing fetal brain does. Now Yale researchers have developed a method to induce growth of blood vessels in organoids and … Read more

Gene regulators work together for oversized impact on schizophrenia risk

Researchers have discovered that gene expression regulators work together to raise an individual’s risk of developing schizophrenia. Schizophrenia-like gene expression changes modeled in human neurons matched changes found in patients’ brains. The researchers, led by Kristen Brennand, of the Icahn School of Medicine at Mount Sinai, New York City, report on their findings in Nature Genetics. … Read more