Precise action anti-cancer drugs in the cell clarified

Scientists from Utrecht University have succeeded in applying advanced microscopy to visualise the activity of the widely used drug Taxol. Taxol is often used in cancer chemotherapy. A better understanding of the precise action of the drug offers starting points for less toxic and effective therapies. Utrecht scientists publish their findings together with international colleagues … Read more

Root of childhood kidney cancer discovered

A fundamental change in our understanding of the childhood kidney cancer Wilms’ tumour is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators. By comparing genome sequences from normal kidney tissue and tumours, the team identified patches of normal-looking kidney tissue that in … Read more

Predicting metastasis from primary tumor size

A new mathematical model uses the size of a cancer patient’s initial, primary tumor to predict whether undetectable secondary tumors are already present. Stefano Avanzini and Tibor Antal of the University of Edinburgh, U.K., present the model in PLOS Computational Biology. As cancer grows, cells can spread from the initial tumor site to other parts of … Read more

3D maps of gene activity

A three-dimensional computer model enables scientists to quickly determine which genes are active in which cells, and their precise location within an organ. A team led by Nikolaus Rajewsky, Berlin, and Nir Friedman, Jerusalem, has published the new method and their insights based on this in Nature. Professor Nikolaus Rajewsky is a visionary: He wants … Read more

Tiny filters help detect cancerous blood cells

Multiple myeloma is a type of blood cancer in which malignant plasma cells, a type of white blood cell, accumulate in the bone marrow. This leads to bone destruction and failure of the marrow, which in healthy individuals, produce all the body’s red blood cells. The most recent data from the American Cancer Society estimates … Read more

Emerging intersections between neuroscience and malignant brain tumors

At first sight it appears implausible that the directed, ordered, and complex development and functionality of the nervous system may share relevant features with such dysregulated, seemingly chaotic malignant brain tumors that we know as yet incurable malignant gliomas. But in the recent years it became evident that brain tumors recapitulate many steps of normal … Read more

Blood cancers: a “new generation” stem cell transplant significantly reduces complications for patients

The discovery of the UM171 molecule, by Dr. Guy Sauvageau and Anne Marinier, made headlines in 2014 following an article in Science. Hailed by some as a revolution, even a miracle, in the field of blood stem cell transplantation, the UM171 molecule is delivering on its promise. After the two-year clinical trial, which used the … Read more