Human gut-in-a-dish model helps define ‘leaky gut,’ and outline a pathway to treatment

Once a vague scapegoat for a variety of ills, increasing evidence suggests a condition known as “leaky gut” – in which microbes and other molecules seep out of the intestines – may be more common, and more harmful, than previously thought. Leaky gut is most often experienced by older people, patients with cancers or other … Read more

New gel boosts cell survival in damaged brain tissue

A novel way to transplant cells using a ‘hydrogel’ offers new hope for people with brain injuries, Parkinson’s disease and stroke patients, according to researchers at The Australian National University (ANU) and Deakin University. The team’s new hydrogel significantly boosts stem cell treatments that target and regenerate damaged brain tissue. The hydrogel – a gel … Read more

Tendon stem cells could revolutionize injury recovery

The buildup of scar tissue makes recovery from torn rotator cuffs, jumper’s knee, and other tendon injuries a painful, challenging process, often leading to secondary tendon ruptures. New research led by Carnegie’s Chen-Ming Fan and published in Nature Cell Biology reveals the existence of tendon stem cells that could potentially be harnessed to improve tendon healing and … Read more

Salmonella – how the body fights back

New research from the University of East Anglia shows how the human body powers its emergency response to salmonella infection. A study, published today in the journal PNAS, reveals how blood stem cells respond in the first few hours following infection – by acquiring energy from bone marrow support cells. It is hoped that the findings … Read more

Blood cancers: a “new generation” stem cell transplant significantly reduces complications for patients

The discovery of the UM171 molecule, by Dr. Guy Sauvageau and Anne Marinier, made headlines in 2014 following an article in Science. Hailed by some as a revolution, even a miracle, in the field of blood stem cell transplantation, the UM171 molecule is delivering on its promise. After the two-year clinical trial, which used the … Read more

Brain stem cells have a good memory

The cerebral cortex acts as the control centre of our cognitive processes. During embryogenesis, dozens of types of neurons with distinct functions come together to form the circuits that drive our thoughts and actions. These neurons are generated by progenitor cells, which produce them one after the other in a very precise order. While neuroscience … Read more

A new method of tooth repair? Scientists uncover mechanisms to inform future treatment

Stem cells hold the key to wound healing, as they develop into specialised cell types throughout the body – including in teeth. Now an international team of researchers has found a mechanism that could offer a potential novel solution to tooth repair. Published today (Friday 9 August) in Nature Communications, the study showed that a gene … Read more

Functional hair follicles grown from stem cells

Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. … Read more

A road map to stem cell development

Johns Hopkins Medicine researchers report they have created a method of mapping how the central nervous system develops by tracking the genes expressed in cells. The technique, demonstrated in mouse retinas for this study, follows the activity of the genes used by individual cells during development, allowing researchers to identify patterns in unprecedented detail. This … Read more