Precise action anti-cancer drugs in the cell clarified

Scientists from Utrecht University have succeeded in applying advanced microscopy to visualise the activity of the widely used drug Taxol. Taxol is often used in cancer chemotherapy. A better understanding of the precise action of the drug offers starting points for less toxic and effective therapies. Utrecht scientists publish their findings together with international colleagues … Read more

Machine learning decreases experimental costs of drug combination screening for translational applications

Combination therapies have become a standard treatment of several complex diseases. High-throughput screening (HTS) makes it possible to profile phenotypic effects of thousands of drug combinations in patient-derived cells and other pre-clinical model systems. However, due to the massive number of potential drug and dose combinations, large-scale multi-dose combinatorial screening requires extensive resources and instrumentation, … Read more

Cutting nanoparticles down to size – new study

Scientists have been investigating how to make better use of nanoparticles in medicine for several decades. Significantly smaller than an average cell, nanoparticles are more similar in size to proteins. This makes them good at interacting with biomolecules and transporting drug molecules attached to their surface across cell membranes. To date, however, only a handful … Read more

Omega-3 shows protection against heart disease-related death, without prostate cancer risk

Should you take omega-3 pills? Or try to have two to servings of omega-3 rich fish a week, as the American Heart Association recommends? It may seem a bit murky if you follow headlines about nutrition and health. That’s why researchers at the Intermountain Healthcare Heart Institute continue to research the potential benefits and risks … Read more

Drug discount cards could actually cost patients more

New research published this week in the Canadian Medical Association Journal (CMAJ) reveals that brand-name drug discount cards are leading to higher health care spending in Canada—increased costs that are ultimately passed on to patients. Brand-name drug discount cards—also known as co-pay cards—are coupons offered by brand drug manufacturers to encourage patients to use brand-name … Read more