Disease-causing protein in cystic fibrosis has ancient roots in sea lamprey

The oldest known ortholog of the ion channel that is defective in patients with cystic fibrosis arose approximately 450 million years ago in the sea lamprey, researchers report October 31st in the journal Developmental Cell. Many differences between lamprey and jawed vertebrate orthologs of this protein, called the cystic fibrosis transmembrane conductance regulator (CFTR), are vestiges … Read more